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SANTA CLARA, Calif. (AP) - Peyton Manning threw a 17-yard touchdown pass to Julius Thomas and dominated in his two series, leading the Denver Broncos past the San Francisco 49ers 34-0 on Sunday to spoil the NFL debut at sparkling $1.2 billion Levi's Stadium.

The 38-year-old Manning, beginning his 17th season after throwing for an NFL-record 55 touchdowns last year, completed 12 of 14 passes for 102 yards and a 120.8 rating. He was 8 for 8 on Denver's second drive, then backup Brock Osweiler took over and threw for a score and led another touchdown drive in a preseason matchup of the past two Super Bowl losers.

Colin Kaepernick went 5 for 9 for 39 yards in his two series before a sellout crowd at the team's flashy new digs in the heart of Silicon Valley. Major League Soccer's San Jose Earthquakes beat the Seattle Sounders in the stadium's first sporting event Aug. 1.

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