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Cleveland, OH (Sports Network) - Jason Giambi stroked a three-run home run and Justin Masterson spun six solid innings to lead the Cleveland Indians to a 5-2 victory over the in-state rival Cincinnati Reds in the opener of a two-game set at Progressive Field.

Cincinnati took the first two games of the Ohio Series at home, but Masterson (8-3) limited the Reds to just one run on four hits and four walks while striking out seven to earn his fourth win in five starts.

Mark Reynolds added a solo shot, while Nick Swisher finished 2-for-4 with an RBI and a run scored to help the Tribe put the brakes on a five-game skid.

Joey Votto and Xavier Paul each hit solo homers, while starter Bronson Arroyo (5-5) was tagged for all five runs on eight hits over 5 2/3 frames in Cincinnati's eighth straight loss in Cleveland.