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WASHINGTON (AP) - The White House says it's "extremely concerned" by the deteriorating situation in southern Ukraine.

The U.S. and Europe have been focused on eastern Ukraine, near Russia, where pro-Russian separatists have been occupying buildings for weeks. But the unrest has spread to Ukraine's southern port of Odessa, where Ukraine's government is seeking to re-establish control.

White House spokesman Jay Carney says the possible loss of Odessa underscores the need for an immediate de-escalation to the crisis. He's suggesting Russia still needs to follow through with its part of a diplomatic deal to de-escalate.

Riots in Odessa led to 46 deaths Friday when a government building was set on fire.

Carney says Ukrainian authorities should launch a full investigation. He says the U.S. mourns with Ukrainians the heartbreaking loss of life.

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