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As many as 10 people were killed and dozens injured Thursday when a charter bus collided with other vehicles and burst into flames in Northern California, authorities said.

California Highway Patrol dispatcher Curtis Pahlka said a FedEx truck crossed the freeway and slammed into the charter bus. Pahlka said a Nissan Altima was also in the collision.

Pahlka said the crash was reported at 5:41 p.m. near the town of Orland, about 100 miles north of Sacramento, and prompted police to close a section of Interstate 5.

The California Highway Patrol offers an update on the fatal bus crash in Orland. News10/KXTV

The crash killed the drivers of the truck and bus, five students and three chaperones, Lt. Bill Carpenter of the highway patrol told CNN.

Glenn County sheriff's dispatcher Pauline Spooner said the bus passengers were high school seniors on their way to visit the campus of Humboldt State University in Arcata, Calif.

Spooner also said several people were airlifted to local hospitals with injuries.

Nine people were killed when a FedEx truck crashed into a tour bus on Interstate 5 near Orland, Calif. Thursday, April 10, 2014. News10

"Humboldt State University is deeply saddened by a tragic accident that occurred earlier this evening involving a charter bus filled with prospective students," the school said in a statement. "They were on their way to visit campus for the April 11 Spring Preview event. Our hearts go out to those who have been affected, and we are here to support them, and their families, in any way possible."

One emergency responder said as many as 37 people needed treatment for injuries such as burns, broken bones and cuts.

"The victims were teenage kids. A lot of them were freaked out. They were shocked. They still couldn't grasp what happened," Jason Wyman with the Orland Volunteer Fire Department told the Associated Press.

Steven Clavijo, 18, a student at West Ranch High School in Santa Clarita, told the AP that he was on the bus during the crash.

Clavijo said he was just getting ready to fall asleep in the back of the bus when he felt the vehicle begin to swerve.

"I just heard this loud boom," he said. "We knew we were in major trouble."

Nine people were killed in a semi-truck and tour bus crash on Thursday, April 10, 2014 News10

Several students escaped through a window one of them had kicked open and were running from the wreckage when the bus exploded behind them, the AP reported.

Tommy Chang, the instructional superintendent for the Los Angeles School District, confirmed that students from Los Angeles schools were involved in the wreck, but he declined to provide further details.

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"These are students who were on an amazing opportunity to see what this amazing state has to offer in terms of higher education," Chang said.

Contributing: William Cummings; The Associated Press

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