San Francisco, CA (Sports Network) - It was a tale of two weeks for the San Francisco 49ers offense.
The Giants defense intercepted Alex Smith three times in New York's 26-3 thumping of the 49ers in a rematch of last season's NFC Championship Game.
Ahmad Bradshaw ran for 116 yards and a score on 27 carries for the Giants (4-2), whose 20-17 overtime win in last season's NFC Championship Game propelled them to their second title in five seasons.
It was the first 100-plus yard rusher allowed by the 49ers defense in 23 games.
Eli Manning was 15-of-28 for 193 yards and a touchdown, Victor Cruz caught six passes for 58 yards and a touchdown and the returning Hakeem Nicks hauled in three passes for 44 yards in the victory.
During last week's 45-3 rout of the Buffalo Bills, San Francisco (4-2) became the first team in NFL history with 300-plus yards passing and 300-or-more yards rushing in a game.
It tallied just 314 total yards against the Giants.
Smith, who came into the game with just one pick on the season, had his first three-interception game since Dec. 20, 2009, during a 27-13 loss to the Philadelphia Eagles.
He finished with 200 yards through the air on 19-of-30 efficiency for the 49ers in the setback.